Automated tangential-flow diafiltration device
نویسندگان
چکیده
منابع مشابه
Protein Concentration and Diafiltration by Tangential Flow Filtration
PURPOSE Membrane-based Tangential Flow Filtration (TFF) unit operations are used for clarifying, concentrating, and purifying proteins. This technical brief is a practical introduction to protein processing using tangential flow filtration. It is intended to help scientists and engineers achieve their protein processing objectives by discussing how the choice of key components and operating par...
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Purpose. The study reports evaluation of different purification processes for removing surplus surfactant and formulating stable nanoparticle dispersions. Methods. Nanoparticle formulations prepared from poly(D,L-lactide-co-glycolide) and polyvinyl alcohol (PVA) were purified by a diafiltration centrifugal device (DCD), using 300K and 100K molecular weight cut-off (MWCO) membranes and a tangent...
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Background: Peritoneal dialysis (PD) is an efficient alternative for hemodialysis. Removal of waste metabolites and excess water from the blood circulation are the two main tasks done during dialysis. These are done by using a filter; in PD, the naturally semi-permeable peritoneal membrane acts as the filter. Automated PD machines control intelligently the operations to enhance the efficiency a...
متن کاملDiafiltration (Buffer Exchange) Using Hollow Fiber Membranes instead of Dialysis Tubing - Automated Diafiltration
Diafiltration is term used reflecting tangential flow filtration (TFF) method of “washing” or removing a permeable molecule (impurities, salts, solvents, small proteins, etc) from a solution in an accelerated method when compared to dialysis tubing. By selecting the appropriate membrane(s), it can also be used to exchange buffers, narrow particle size distributions, modify salt concentrations o...
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This study concentrates on time-optimal operation of a general batch diafiltration process. The process model consists of a set of input affine differential equations. We apply Pontryagin’s minimum principle to formulate necessary conditions of optimality. These are then used to identify the shape of optimal control as well as singular surface in concentration space. Comparison is made between ...
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ژورنال
عنوان ژورنال: HardwareX
سال: 2021
ISSN: 2468-0672
DOI: 10.1016/j.ohx.2021.e00200